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Monkeypox Outbreak Strain Has Far More Mutations Than Expected

The strain of monkeypox involved in the current global outbreak differs from its parent strain by about 50 single nucleotide polymorphisms (SNPs) -- far more than would be expected for an orthopoxvirus, researchers reported.

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A 4th vaccine shot provided benefits to patients hospitalized with severe covid--Israel study

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac501/6611845

Hospitalized patients with severe COVID-19 during the Omicron wave benefited from a 4th vaccine shot--Israeli study

Waning vaccine-immunity and an increased incidence of COVID-19 during the Omicron outbreak led the Israeli Ministry of Health to recommend a fourth dose of BNT162b2 for high-risk individuals. This study assessed the effect of that dose for hospitalized patients with severe/critical, breakthrough COVID-19. ...

Among hospitalized patients with severe/critical breakthrough COVID-19, a recent fourth dose was associated with significant protection against mechanical ventilation or death, compared to three doses.

 

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